Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications 2013th Edition

Ebook Details

Year 2013
Pages 348
Publisher Springer
Language en
ISBN 9781461461814
File Size 5.16 MB
File Format PDF
Download Counter 82
Amazon Link

Ebook Description

Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males.  AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes.  Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer.   This volume provides critical information from  well respected experts in the field.  Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT).  Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function.  This book is intended for researchers, scientists, faculty, and advanced graduate students  with an interest in androgen action and prostate cancer.​ QR Code Online