This volume contains the proceedings of the International Conference on Group Theory, Combinatorics and Computing held from October 3-8, 2012, in Boca Raton, Florida. The papers cover a number of areas in group theory and combinatorics. Topics include finite simple groups, groups acting on structured sets, varieties of algebras, classification of groups generated by 3-state automata over a 2-letter alphabet, new methods for construction of codes and designs, groups with constraints on the derived subgroups of its subgroups, graphs related to conjugacy classes in groups, and lexicographical configurations. Application of computer algebra programs is incorporated in several of the papers. This volume includes expository articles on finite coverings of loops, semigroups and groups, and on the application of algebraic structures in the theory of communications. This volume is a valuable resource for researchers and graduate students working in group theory and combinatorics. The articles provide excellent examples of the interplay between the two areas.