mGLU Receptors 1st ed. 2017 Edition

Ebook Details


Richard Teke Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia

Year 2017
Pages 282
Publisher Humana Press
Language en
ISBN 9783319561684
File Size 4.33 MB
File Format PDF
Download Counter 91
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Ebook Description

Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the bain and peripheral tissues. This volume will focus on the latest research in the role of Group I mGluRs in health and disease.